VITAMIN C REDUCTION OF F. INDUCED EMBRYO-TOXICITY IN RATS

See also:

Ameliorative Effects of Quercetin on
Sodium Fluoride-Induced Oxidative
Stress in Rat’s Kidney

 

These finding suggest that vitamin C
significantly reduced the severity and incidence
of fluoride-induced embryo toxicity in rats.

Guinea pigs, apes, [some] fruit bats and humans share
another trait: The tendency to develop coronary heart
disease. The development of heart disease only
occurs in animals and humans that lack adequate
intake of ascorbates through dietary sources.

.

Jai Research Foundation,
Vapi, Valvada 396 108,
India

    Oral administration of sodium fluoride (40 mg/kg body weight)from day 6 to 19 of gestation caused, as comparedto control, significant reductions in body weight, feed consumption, absolute uterine weight and numberof implantations. Significantly higher incidenceof skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternebrae, incompleteossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were alsoobserved in NaF-treated dams than that of control.Oral administration of vitamin C (50 mg/kg bodyweight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) fromday 6 to 19 of gestation along with NaF significantlyameliorates NaF-induced reductions in body weight,feed consumption, absolute uterine weight (only with vitaminE treatment) and number of implantations. Ascompared with NaF-treated alone, the total percentageof skeletal and visceral abnormalities were significantly loweredin fluoride plus vitamin C-treated animals.Vitamin E was less effective.

These finding suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryo toxicity in rats.

Key Words: fluoride • vitamins • embryotoxicity • amelioration

Human & Experimental Toxicology, Vol. 20, No. 12, 619-623 (2001)

 

See ⇒ Fruit bats 

Progressive Pseudogenization:

Vitamin C Synthesis & Its Loss in Bats

See also ⇒ BATS