VITAMIN C REDUCTION OF F. INDUCED EMBRYO-TOXICITY IN RATS

These finding suggest that vitamin C
significantly reduced the severity and
incidence of fluoride-induced embryo toxicity in rats.

Vit C Rats F. Verma

Jai Research Foundation, Vapi, Valvada 396 108, India

Oral administration of sodium fluoride (40 mg/kg body weight)from day 6 to 19 of gestation caused, as comparedto control, significant reductions in body weight, feed consumption, absolute uterine weight and numberof implantations. Significantly higher incidenceof skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternebrae, incompleteossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were alsoobserved in NaF-treated dams than that of control.Oral administration of vitamin C (50 mg/kg bodyweight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) fromday 6 to 19 of gestation along with NaF significantlyameliorates NaF-induced reductions in body weight,feed consumption, absolute uterine weight (only with vitaminE treatment) and number of implantations. Ascompared with NaF-treated alone, the total percentageof skeletal and visceral abnormalities were significantly loweredin fluoride plus vitamin C-treated animals.Vitamin E was less effective.

These finding suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryo toxicity in rats.

Key Words: fluoride • vitamins • embryotoxicity • amelioration

Human & Experimental Toxicology, Vol. 20, No. 12, 619-623 (2001)

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