VITAMIN C REDUCTION OF F. INDUCED EMBRYO-TOXICITY IN RATS

These finding suggest that vitamin C
significantly reduced the severity and
incidence of fluoride-induced embryo toxicity in rats.

Guinea pigs, apes, some fruit bats and humans share another trait: 
The tendency to develop coronary heart disease. 
The development of heart disease only occurs in animals and
humans that lack adequate intake of ascorbates through dietary sources.

 

Jai Research Foundation,
Vapi, Valvada 396 108,
India

 

    Oral administration of sodium fluoride (40 mg/kg body weight)from day 6 to 19 of gestation caused, as comparedto control, significant reductions in body weight, feed consumption, absolute uterine weight and numberof implantations. Significantly higher incidenceof skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternebrae, incompleteossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were alsoobserved in NaF-treated dams than that of control.Oral administration of vitamin C (50 mg/kg bodyweight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) fromday 6 to 19 of gestation along with NaF significantlyameliorates NaF-induced reductions in body weight,feed consumption, absolute uterine weight (only with vitaminE treatment) and number of implantations. Ascompared with NaF-treated alone, the total percentageof skeletal and visceral abnormalities were significantly loweredin fluoride plus vitamin C-treated animals.Vitamin E was less effective.

These finding suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryo toxicity in rats.

Key Words: fluoride • vitamins • embryotoxicity • amelioration

Human & Experimental Toxicology, Vol. 20, No. 12, 619-623 (2001)

      See also –
Natural cure zone.-guinea pigs, apes, fruit bats, & humans