VITAMIN C REDUCTION OF F. INDUCED EMBRYO-TOXICITY IN RATS

See also:

Ameliorative Effects of Quercetin on
Sodium Fluoride-Induced Oxidative
Stress in Rat’s Kidney

These finding suggest that vitamin C
significantly reduced the severity and incidence
of fluoride-induced embryo toxicity in rats.

Guinea pigs, apes, [some] fruit bats and humans share
another trait: The tendency to develop coronary heart
disease. The development of heart disease only
occurs in animals and humans that lack adequate
intake of ascorbates through dietary sources.

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Jai Research Foundation,
Vapi, Valvada 396 108,
India

    Oral administration of sodium fluoride (40 mg/kg body weight)from day 6 to 19 of gestation caused, as comparedto control, significant reductions in body weight, feed consumption, absolute uterine weight and numberof implantations. Significantly higher incidence of skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternal brae, incomplete ossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were also observed in NaF-treated dams than that of control.Oral administration of vitamin C (50 mg/kg bodyweight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) from day 6 to 19 of gestation along with NaF significantly ameliorates NaF-induced reductions in body weight, feed consumption, absolute uterine weight (only with vitamin E treatment) and number of implantations. As compared with NaF-treated alone, the total percentage of skeletal and visceral abnormalities were significantly lowered in fluoride plus vitamin C-treated animals. Vitamin E was less effective.

These finding suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryo toxicity in rats.

Key Words: fluoride • vitamins • embryotoxicity • amelioration

Human & Experimental Toxicology, Vol. 20, No. 12, 619-623 (2001)

 

See ⇒ Fruit bats 

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Progressive Pseudogenization:

Vitamin C Synthesis & Its Loss in Bats

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See also ⇒ BATS

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