On poor diets, low in Vit. C humans and guinea pigs will suffer more damage than most other animals even on low doses of fluoride. Guinea pigs are therefor better experimental animals than rats or mice.
Vitamin C Supplements for Guinea Pigs Authored by: Dr. Jeff Rhody, DVM
For the biologic machinery of the body to work correctly, vitamin C is required. Most animals can manufacture vitamin C in their bodies and do not require vitamin C in their diet.
Guinea pigs, humans, and other primates share a gene mutation that makes production of vitamin C impossible. For this reason, these animals require a dietary source of vitamin C.
Guinea pigs who do not receive enough vitamin C in their diet can suffer from vitamin C deficiency (commonly known as scurvy in humans). Affected guinea pigs may have a rough hair coat, lack of appetite, dental pain, delayed wound healing, lameness, and an inability to fend off infections. Guinea pigs with a slight vitamin C deficiency may show no visible signs of disease; however, their immune system may be compromised leading to decreased ability to fight off other illnesses….