Thank you Dr. Mercola

Helpful Protocol to Minimize Damage of Alcohol

While I don’t recommend drinking alcohol, if you know you’ll be having a few drinks, taking this natural protocol beforehand can help “pre-tox” your body, thereby minimizing the damage associated with alcohol consumption. Just beware that this protocol will NOT make you less susceptible to alcohol poisoning or other acute adverse events associated with binge drinking, so please use common sense and drink responsibly. 

• N-acetyl cysteine (NAC): NAC is a form of the amino acid cysteine. It is known to help increase glutathione and reduce acetaldehyde toxicity that causes many hangover symptoms.25 Try taking NAC (at least 200 milligrams) 30 minutes before you drink to help lessen the alcohol’s toxic effects.

If you’re wondering just how powerful NAC can be, consider that, like alcohol, one way that Tylenol causes damage to your liver is by depleting glutathione. If you keep your glutathione levels up, the damage from the acetaminophen may be largely preventable. This is why anyone who overdoses on Tylenol receives large doses of NAC in the emergency room — to increase glutathione.

• B Vitamins: NAC is thought to work even better when combined with vitamin B1 (thiamine).26 Vitamin B6 may also help to lessen hangover symptoms. Since alcohol depletes B vitamin in your body, and the B vitamins are required to help eliminate alcohol from your body, a B-vitamin supplement taken beforehand, as well as the next day, may help. 

• Milk Thistle: Milk thistle contains silymarin and silybin, antioxidants known to help protect your liver from toxins, including the effects of alcohol. Not only has silymarin been found to increase glutathione, but it also may help to regenerate liver cells.27 A milk thistle supplement may be most useful when taken regularly, especially if you know you’ll be having cocktails on more than one occasion. 

• Vitamin C: Alcohol may deplete your body of vitamin C, which is important for reducing alcohol-induced oxidative stress in your liver. Interestingly, one animal study showed vitamin C was even more protective to the liver than silymarin (milk thistle) after exposure to alcohol.28

Making sure you’re getting enough vitamin C, either via supplements or food, is another trick to use prior to indulging in alcoholic beverages. Vitamin C is actually such a powerful detoxifier that if you take large doses prior to receiving dental anesthesia, the anesthesia will be significantly weakened and may not work. 

• Magnesium: Magnesium is another nutrient depleted by alcohol, and it’s one that many are already deficient in. Plus, magnesium has anti-inflammatory properties that may help to reduce some hangover symptoms. If you don’t eat a lot of magnesium-rich foods, taking a magnesium supplement before an evening involving drinking may be helpful.